JU-YEON LEE1, DAEUN MOON2, JINU KIM2,3,*
BIOCELL, Vol.49, No.1, pp. 79-92, 2025, DOI:10.32604/biocell.2024.058340
- 24 January 2025
Abstract
The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses. This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases. EGFR signaling is essential for kidney function and repair mechanisms, and its dysregulation significantly impacts both acute and chronic kidney conditions. The review discusses the normal distribution of EGFR in kidney tubular segments, the mechanism of its activation and inhibition, and the therapeutic potential of EGFR-targeting antagonists and ligands. Additionally, it explores the pathophysiological characteristics observed More >
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