YANGYI HE1,2, DAVID SANCHEZ-LORENTE3,4,5, MELISSA ACOSTA-PLASENCIA1, MARC BOADA3,4,5, ANGELA GUIRAO3,4,5, RAMON M. MARRADES4,5,6,7, LAUREANO MOLINS3,4,5, ALFONS NAVARRO1,4,5,*
BIOCELL, Vol.47, No.5, pp. 951-957, 2023, DOI:10.32604/biocell.2023.027718
Abstract Tumor-secreted extracellular vesicles (EVs) participate in the metastasis process through different mechanisms, including the preparation of the pre-metastatic niche to grant circulating tumor cells (CTCs) implantation and growth. The study of the metastasis process through the analysis of CTCs and tumor-derived EVs is difficult because of the dilution grade of these elements in peripheral blood. In early-stage lung cancer patients, the tumor-secreted products are even more diluted. An attractive strategy in surgical lung cancer patients is to purify them from a pulmonary tumor-draining vein where they are enriched. The information obtained from the analysis of EVs and CTCs purified from… More >
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