XINGYU MEI, ZHOUWEI WU, CHENGZHONG ZHANG, YUE SUN, WEIMIN SHI*
BIOCELL, Vol.45, No.6, pp. 1551-1559, 2021, DOI:10.32604/biocell.2021.015376
Abstract Vitiligo results in an autoimmune disorder destructing skin pigment cells, melanocytes (Mcs). This study aimed
to investigate whether Astragaloside IV (AIV) could efficiently induce differentiation of bone marrow mesenchymal stem
cells (BMMSCs) into Mcs. BMMSCs were induced and differentiated into Mcs with 0.1, 0.2, and 0.4 mg/L AIV during
150-day. Morphologic changes of differentiated cells were observed. Levels of some melanocytic specific genes (TRP-1,
TRP-2, MART-1, Mitf) were measured with quantitative polymerase chain reaction (qPCR) at 90, 120, and 150 days
of induction. After 90-day induction, the differentiated cells with 0.4 mg/L AIV demonstrated the typical morphology
of Mcs, positive… More >
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