Jie Xu*1,
Zhongzhou Su*1,
Qiuping Ding†, Liang Shen*, Xiaohu Nie*, Xuyan Pan*, Ai Yan*,
Renfu Yan*, Yue Zhou*, Liqin Li‡, Bin Lu*
Oncology Research, Vol.27, No.7, pp. 819-826, 2019, DOI:10.3727/096504018X15478559215014
Abstract Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM
proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However,
the roles of TMEM168 in human GBM remain poorly understood. Herein we found that mRNA levels of
TMEM168 were overexpressed in GBM patients (n=85) when compared with healthy people (n=10),
which was also supported by data from The Cancer Genome Atlas (TCGA). Kaplan–Meier analysis of Gene
Expression Omnibus dataset GSE16011 suggested that enhanced TMEM168 expression was associated with
shorter survival time. To investigate whether and how TMEM168 functioned in… More >
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