WENZHUO YANG1,#, HAODONG CHEN2,#, ZHILAN ZHANG3, ZHIYONG XIA3, YUANYUAN JIN1,*, ZHAOYONG YANG1,*
Oncology Research, Vol.33, No.6, pp. 1485-1494, 2025, DOI:10.32604/or.2025.059426
- 29 May 2025
Abstract Background: Human natural killer (NK) cells have attracted widespread attention as a potential adoptive cell therapy (ACT). However, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. There is an urgent need to explore a suitable new treatment plan to overcome weaknesses and support the superior therapeutic activity of NK cells. Methods: In this study, the mechanisms underlying the susceptibility of gastric cancer (GC) cell lines AGS, HGC-27, and NCI-N87 to NK cell-mediated cytotoxicity were explored. Results: Lactic dehydrogenase (LDH) release assays showed that all three GC cell lines were susceptible… More >
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