WEI XIA1, NING YANG2, XIAOYAN FENG3, TING XIN1, YONGLE JING1, YUMING LI4,*, CHENGZHI LU1,5,*
BIOCELL, Vol.47, No.4, pp. 837-847, 2023, DOI:10.32604/biocell.2023.026161
Abstract Background: Preeclampsia (PE), characterized by hypertension and proteinuria, leads to serious maternal and
infant complications. Uridine-cytidine kinase 2 (UCK2) belongs to the UCK family, a class of enzymes that catalyzes the
conversion of uridine and cytidine to monophosphate form. However, the role of UCK2 in PE has not been reported.
Methods: The expression of UCK2 was detected in the placenta of PE patients and N(ω)-nitro-L-arginine methyl esterinduced PE mouse model. Through forced up-regulation or down-regulation of UCK2 in vitro, we examined the effects of
UCK2 on the proliferation, apoptosis, migration, and invasion of trophoblast cells. Stattic, the inhibitor of STAT3… More >
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