VALERIA C. DENNINGHOFF1,2*, GEORGINA P. OSSANI1, ANA M. UCEDA1, MARIA A. AVAGNINA2, BORIS ELSNER2, ALBERTO J. MONSERRAT1
BIOCELL, Vol.34, No.2, pp. 65-70, 2010, DOI:10.32604/biocell.2010.34.065
Abstract Weanling Sprague-Dawley rats were fed on a choline-deficient diet with hydrogenated vegetable oil and corn oil as lipids develop acute renal failure. Pathogenesis of the latter is controversial and an ischemic mechanism has been proposed. Arachidonic acid derivatives are involved in the regulation of vascular tonus. Vasospasm could be due to an increase in tromboxane A2-mediated vasoconstriction or to a decrease in prostacyclin-induced vasodilatation. Enzymes involved in the synthesis of both compounds are tromboxane A2- and prostacyclin-synthase respectively. The aim of this study was to identify the variable number tandem repeats (VNTR) in the promoter region of prostacyclin synthase gene… More >
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