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    Some Aspects in Mechano-Biology of Platelet and Leukocyte in Blood Flows

    Ying Fang1, Jianhua Wu1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 5-6, 2019, DOI:10.32604/mcb.2019.05695

    Abstract For hemostasis and thrombosis, some proteins, such as Von Willebrand Factor (VWF, a multimeric plasma glycoprotein synthesized in endothelial cells and megakaryocytes and secreted to circulation or attached to endothelial cells), the metalloprotease ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13), P-selectin (one of three selectin family members with a N-terminal C-type lectin domain, an epidermal growth factor (EGF)-like module, a series of consensus repeat (CR) units, a transmembrane segment and a short cyto-plasmic domain) and β2 integrin. In adhesion and aggregation of circulating platelets towards to the sites of… More >

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