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    ARTICLE

    Ala-Gln improves varicocele-induced testicular injury by increasing HSP70 and antioxidant activity in male rats

    LEI YU1,2, ZHEN FAN3, HONGQIANG WANG2, WENXIAN LI4, TAO JING2, QIANG LI2, SHENQIAN LI2, PEITAO WANG2, XUJUN XUAN1,*

    BIOCELL, Vol.45, No.2, pp. 323-329, 2021, DOI:10.32604/biocell.2021.09034

    Abstract This worked aimed to test the hypothesis that L-alanyl-L-glutamine (Ala-Gln) improves the varicocele-induced testicular injury, which causes male infertility. For this purpose, fifty adult male Wistar rats received the varicocele (VC) surgery at the left renal vein. Biomarkers were determined 2, 4, and 8 weeks after VC (n = 10/each detection). Four weeks after VC, rats received Ala-Gln (1.125 g/kg) treatment with and or saline for 1 week (n = 10/each group). Rats in the sham group were also detected for biomarkers at 2, 4, and 8 weeks (n = 10/each detection). VC caused testicular injury detected by hematoxylin–eosin (H&E)… More >

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