YU ZHANG1,2, XI’AN ZHOU1,2, CHUNYAN ZHANG1,2, DENGNI LAI5, DONGBO LIU1,3,4, YANYANG WU1,2,3,4,*
BIOCELL, Vol.47, No.4, pp. 859-868, 2023, DOI:10.32604/biocell.2023.026429
Abstract Background: Hyperglycemia is a typical symptom of diabetes. High glucose induces apoptosis of islet β cells. While autophagy functions in cytoprotection and autophagic cell death. The interaction between autophagy and apoptosis is important in the modulation of the function of islet β cells. Vitamin B3 can induce autophagy and inhibit islet β apoptosis.Method: The mechanism of vitamin B3-mediated protective effect on the function of islet β cells was explored by the method of western blot, immunofluorescence and flow cytometry.Results: In the present study, high glucose stress increased the apoptosis rate, while vitamin B3 reduced the apoptosis rate. The effect of… More >
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