Annette Doyle*, Steven R. Crosby†, David R. Burton*, Francis Lilley*, Gary Johnston*, Winder B. Perez‡, Terri G. Kinzy‡, Mark F. Murphy*,†,§
Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 275-288, 2013, DOI:10.3970/mcb.2013.010.275
Abstract Many diseases including cancer are associated with a disorganised cytoskeleton. The process of characterising how cytoskeletal disorganisation affects the mechanical properties of cells offers the potential to develop new drugs and treatment regimes that may exploit mechanical weakness in cells and tissues. This work investigated the role of actin associated proteins, namely tropomyosin 1 (tpm1p) and mitochondrial distribution and morphology protein 20 (mdm20p), on the mechanical and morphological properties of yeast cells. For the first time it was shown that deletion of both the TPM1 and MDM20 genes resulted in a decrease in Young’s modulus when compared to the wild-type… More >
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