Sumayh S. Aljameel¹, Malak Aljabri^1,2, Nida Aslam¹, Dorieh M. Alomari^3,*, Arwa Alyahya¹, Shaykhah Alfaris¹, Maha Balharith¹, Hiessa Abahussain¹, Dana Boujlea¹, Eman S. Alsulmi⁴

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1291-1304, 2023, DOI:10.32604/cmc.2023.035710

Abstract Currently, the risk factors of pregnancy loss are increasing and are considered a major challenge because they vary between cases. The early prediction of miscarriage can help pregnant ladies to take the needed care and avoid any danger. Therefore, an intelligent automated solution must be developed to predict the risk factors for pregnancy loss at an early stage to assist with accurate and effective diagnosis. Machine learning (ML)-based decision support systems are increasingly used in the healthcare sector and have achieved notable performance and objectiveness in disease prediction and prognosis. Thus, we developed a model to help obstetricians predict the… More >

JIABAO WU^1,2,#, XIAOHUA LIU^1,2,#, LU HAN^1,2, HUA NIE^1,2, YUAN TANG^1,2, YUNGE TANG^1,3, GE SONG^1,5, LIXIN ZHENG^1,4, WEIBING QIN^1,2,*

BIOCELL, Vol.46, No.4, pp. 1013-1023, 2022, DOI:10.32604/biocell.2022.016744

Abstract Piwi-interacting RNAs (piRNAs) is a novel class of non-coding RNAs. However, changes in piRNA expression profiles in recurrent spontaneous abortion (RSA) have not yet been investigated. The aim of this study was to identify differentially expressed piRNAs in deciduas of RSA patients. Decidua tissues were collected by curettage from recruited RSA patients and normal early pregnant (NEP) women with their informed consent. Small RNA sequencing was used to evaluate the differences in piRNA expression profiles between RSA and NEP. The present results demonstrated that the counts of total piRNA reads in RSA samples were increased compared with those in NEP… More >

AFRAH ALKHURIJI¹, ATEKAH ABDULLAH MOHAMMED ALRAQIBAH¹, AMAAL AWAD ALHARBI¹, ZENEB BABAY², FATIMAH BASIL AL-MUKAYNIZI³, ARWA ALTHOMALI³, SONYA S. ABDEL-RAZEQ⁴, ARJUMAND S. WARSY⁵

BIOCELL, Vol.44, No.4, pp. 613-621, 2020, DOI:10.32604/biocell.2020.09652

Abstract Methylenetetrahydrofolate reductase (MTHFR) deficiency is the most common genetic cause of hyperhomocysteinemia, which has been implicated in the etiology of recurrent spontaneous abortion (RSA). This study was designed to investigate the association between two single nucleotide polymorphisms (SNP) (rs1801133 [C677T] and rs1801131 [A1298C]) in the MTHFR gene and RSA, in Saudis. These two SNPs were selected as these polymorphisms have a different effect on the activity and stability of the enzyme, and significantly diverse effects have been reported in relation to the association with RSA. Ethical approval was acquired from the IRB at King Saud University (KKUH), Saudi Arabia, and… More >