John M. Ferguson
Congenital Heart Disease, Vol.14, No.1, pp. 52-56, 2019, DOI:10.1111/chd.12715
Abstract Even though up to 60% of premature infants less than 28 weeks gestation develop
persistent patent ductus arteriosus (PDA), there remains controversy regarding if,
when, and how to close the PDA. Failure to close the PDA has been associated with
significant morbidity but no cause‐and‐effect has been proven for short‐term or
long‐term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short‐term complications and long‐term adverse outcomes are worrisome. Intravenous indomethacin has been the “gold standard” for pharmacologic
treatment over the past 40 years with high closure rates and decreased incidence of
severe intraventricular hemorrhage… More >
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