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  • Open Access


    The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis


    BIOCELL, Vol.46, No.9, pp. 2003-2007, 2022, DOI:10.32604/biocell.2022.020171

    Abstract Hepatic stellate cells (HSCs) are the primary effector cells in liver fibrosis. In the normal liver, HSCs serve as the primary vitamin A storage cells in the body and retain a “quiescent” phenotype. However, after liver injury, they transdifferentiate to an “activated” myofibroblast-like phenotype, which is associated with dramatic upregulation of smooth muscle specific actin and extracellular matrix proteins. The result is a fibrotic, stiff, and dysfunctional liver. Therefore, understanding the molecular mechanisms that govern HSC function is essential for the development of anti-fibrotic medications. The actin cytoskeleton has emerged as a key component of the fibrogenic response in wound… More >

  • Open Access


    Multiscale Modeling of Clathrin-Mediated Endocytosis

    Padmini Rangamani1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 22-22, 2019, DOI:10.32604/mcb.2019.08513

    Abstract Endocytosis is the process of uptake of cargo and fluid from the extracellular space to inside the cell; defects in endo- cytosis contribute to a wide spectrum of diseases including cancer, neurodegeneration, and heart disease. Clathrin- mediated endocytosis (CME) is an archetypal example of a membrane deformation process where multiple variables such as pre-existing membrane curvature, membrane bending due to the protein machinery, membrane tension regulation, and actin-mediated forces govern the progression of vesiculation. My group has been working for the past few years on deciphering the biophysical determinants of CME using multiscale modeling. We recently showed that membrane tension… More >

  • Open Access


    Short-Term Shear Stress Induces Rapid Actin Dynamics in Living Endothelial Cells

    Colin K. Choi*, Brian P. Helmke∗,†

    Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 247-258, 2008, DOI:10.3970/mcb.2008.005.247

    Abstract Hemodynamic shear stress guides a variety of endothelial phenotype characteristics, including cell morphology, cytoskeletal structure, and gene expression profile. The sensing and processing of extracellular fluid forces may be mediated by mechanotransmission through the actin cytoskeleton network to intracellular locations of signal initiation. In this study, we identify rapid actin-mediated morphological changes in living subconfluent and confluent bovine aortic endothelial cells (ECs) in response to onset of unidirectional steady fluid shear stress (15 dyn/cm2). After flow onset, subconfluent cells exhibited dynamic edge activity in lamellipodia and small ruffles in the downstream and side directions for the first 12 min; activity… More >

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