Benjamin M. Moore1,2, Rachael L. Cordina1,2, Mark A. McGuire1,2, David S. Celermajer1,2
Congenital Heart Disease, Vol.13, No.6, pp. 944-951, 2018, DOI:10.1111/chd.12657
Abstract Objective: Amiodarone is a highly effective antiarrhythmic therapy, however its tox‐
icity profile often limits treatment. This is particularly relevant in adults with congeni‐
tal heart disease (CHD), who are often young and in whom other antiarrhythmic
agents commonly fail or are contraindicated. We sought to determine incidence and
predictors of adverse effects caused by amiodarone in adult CHD (ACHD).
Design: A retrospective review of patients with moderate to complex ACHD treated
with amiodarone at our center between 2000 and 2017 was performed. Incidence
and predictors of adverse effects were described. Efficacy of amiodarone therapy in
controlling the clinical arrhythmia… More >
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