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  • Open Access


    Differential Organization of Airway Smooth Muscle Cells on Tubular Surface as A Novel Mechanobiology Mechanism of Airway Tissue Morphogenesis

    Linhong Deng1,*, Yang Jin2, Mingzhi Luo1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 80-80, 2019, DOI:10.32604/mcb.2019.07370

    Abstract Airway smooth muscle cells (ASMCs) exists within the bronchial airway wall in a form of spirally winding bundles [1]. This pattern emerges early during embryonic development and is involved in airway branching [2], providing the airway appropriate contractile capacity and resistance to circumferential tension in health or causing excessive airway narrowing in disease such as asthma. Despite its importance, the cause of ASMCs self-organization remains largely a mystery. Previously, we have demonstrated in 2D that ASMCs can sense the curvature in their microenvironment and change behaviors in differentiation, orientation and migration accordingly [3]. Here we… More >

  • Open Access


    Sensing Traction Force Induces Cell-Cell Distant Communications for the Rapid Network Assembly of Airway Smooth Muscle Cells

    Mingxing Ouyang1,*, Zhili Qian1, Yang Jin1, Linhong Deng1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 65-65, 2019, DOI:10.32604/mcb.2019.06642

    Abstract The collective functions at cell population level rely on cell-cell communications with or without direct contacts [1-3]. The long-range biomechanical force propagating across certain scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population [3-5]. Whether and how cells communicate with each other mechanically in a distant manner remains largely to be explored. Airway smooth muscle (ASM) cells are one crucial component in providing mechanical support and contraction force for the bronchial tubes in respiratory system, whereas the mechanical property of ASM is also associated with asthma… More >

  • Open Access


    Sanguinarine Decreases Cell Stiffness and Traction Force and Inhibits the Reactivity of Airway Smooth Muscle Cells in Culture

    Mingzhi Luo1, Kai Ni1, Peili Yu1, Yang Jin2, Lei Liu1, Jingjing Li1, Yan Pan1, Linhong Deng1,*

    Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 141-151, 2019, DOI:10.32604/mcb.2019.06756

    Abstract Airway hyperresponsiveness (AHR) is the cardinal character of asthma, which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells (ASMCs). Therefore, these biomechanical properties comprise logical targets of therapy. β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma. However, this drug is known for side effects such as desensitization and non-responsiveness in some patients. Therefore, it is desirable to search for new drug agents to be alternative of β2-adrenergic agonist. In this context, sanguinarine, a natural product derived from plants such… More >

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