Analia G. Karadayian1, Juanita Bustamante2, Silvia Lores-Arnaiz1, *
BIOCELL, Vol.40, No.1, pp. 31-34, 2016, DOI:10.32604/biocell.2016.40.031
Abstract Alcohol hangover (AH) is defined as the temporary state after alcohol binge-like drinking, starting
when EtOH is absent in plasma. Results from our laboratory have shown behavioral impairments and mitochondrial dysfunction in an experimental model of AH in mice. Our model consisted in a single i.p. injection of EtOH
(3.8 g/kg BW) or saline solution in male and female mice, sacrificing the animals 6 hours after injection. Motor and
affective behavior together with mitochondrial function and free radical production were evaluated in brain cortex
and cerebellum during AH. Results showed that hangover animals exhibited a significant reduction in neuromuscular coordination,… More >
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