Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Oleh Koshovyi¹, Amal D. Premarathna², Rando Tuvikene², Valdas Jakštas^3,4, Vaidotas Žvikas³, Yurii Hrytsyk⁵, Lyubov Grytsyk⁵, Andriy Grytsyk⁵, Jaan Liira⁶, Ain Raal^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3991-4019, 2025, DOI:10.32604/phyton.2025.074153 - 29 December 2025

Abstract Gilia capitata Sims (Polemoniaceae) is an annual herbaceous plant widely distributed in western North America and cultivated as an ornamental flower. The detailed chemical composition and pharmacological properties of this plant have not been previously reported. This study aimed to investigate the chemical composition and pharmacological activity of aqueous-ethanolic extracts derived from different plant parts (herb, flowers, stems, roots, and fruits). HPLC analysis identified 12 phenolic compounds and 16 amino acids in the aqueous-ethanolic extracts obtained from these plant parts. The biological effects of the extracts were evaluated in vitro, including cytotoxicity, anti-inflammatory response, and wound-healing potential.… More >

Lesya Voytenko^1,*, Mykola Shcherbatiuk¹, Valentyna Vasyuk¹, Kateryna Romanenko¹, Lidiya Babenko¹, Oleksandr Smirnov^2,3, Iryna Kosakivska¹

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 2195-2214, 2025, DOI:10.32604/phyton.2025.067772 - 31 July 2025

Abstract Prolonged lack of rain and high-temperature lead to soil water deficits, inhibiting cereal crop growth in early ontogenesis and reducing grain quality and yield. Rye (Secale cereale L.) is a key grain crop, particularly in regions where wheat cultivation is challenging or unfeasible. To clarify its drought adaptation mechanisms, we analyzed the effects of moderate soil drought on growth, hormonal homeostasis, and the dynamics and distribution of free amino acids and phenolic compounds in rye at early vegetative stages and post-recovery. Drought triggered both general and organ-specific changes in endogenous phytohormones. A nonspecific response involved the… More >

Juan Francisco Zamora Natera^1,*, Mario Felipe González González¹, Javier Vioque², Julio Girón-Calle², Manuel Alaiz²

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1533-1544, 2025, DOI:10.32604/phyton.2025.064966 - 29 May 2025

Abstract Jarilla caudata Standl. (Caricaceae) is a wild herbaceous plant native to Mexico recognized for its edible fruits. It is considered to be the closest taxonomically species to Carica papaya L. (Caricaceae), whose seeds have good nutritional and functional properties. This study analyzes and compares the seed chemical compositions of J. caudata and C. papaya to study the nutritional and functional potential of J. caudata seeds. The analysis of the proximate composition was based on standard methods. High-performance liquid chromatography was used to determine the free amino acid profile, gas chromatography to quantify the fatty acid content, and inductively coupled plasma–optical… More > Graphic Abstract

Oleh Koshovyi^1,2,*, Janne Sepp¹, Valdas Jakštas³, Vaidotas Žvikas³, Karina Tolmacheva⁴, Igor Kireyev⁴, Jyrki Heinämäki¹, Ain Raal^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2909-2925, 2024, DOI:10.32604/phyton.2024.056536 - 30 November 2024

Abstract Pineappleweed (Matricaria discoidea DC., Asteraceae) herb is an essential oil containing raw material with spasmolytic and anti-inflammatory activity. It is also rich in phenolics, which may be used in pharmaceutical practice. This study aimed to investigate the phenolic and amino acid composition and the hyporific and analgesic effects of the M. discoidea aqueous-ethanolic extract and its amino acid modifications. In addition, we developed a polyethylene oxide gel formulation with M. discoidea extracts for the 3D-printed oral solid dosage preparations. In M. discoidea extracts, 16 phenolic substances and 14 amino acids were established. The extract and its amino acid preparations More >

Yurii Hrytsyk¹, Oleh Koshovyi^2,3, Martin Lepiku⁴, Valdas Jakštas⁵, Vaidotas Žvikas⁵, Tetiana Matus¹, Mariia Melnyk¹, Lyubov Grytsyk¹, Ain Raal^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2303-2315, 2024, DOI:10.32604/phyton.2024.055117 - 30 September 2024

Abstract Canadian goldenrod (Solidago canadensis L.) is a rhizomatous plant of the Asteraceae family. In folk medicine, Solidago galenic remedies are used for diseases of the kidneys, urinary tract, liver, etc. Externally, goldenrod is used to treat purulent wounds, furunculosis, and gum abscesses as washes and compresses. The aims of this research were to study the yield and chemical composition of essential oil (EO), the anti-inflammatory activity of S. canadensis dry extracts based on its decoction and tincture. In EO (2.8 mL/kg) of S. canadensis were identified and quantified 34 compounds. The principal compounds of the EO from flowering tops… More > Graphic Abstract

Esra Arslan Yuksel^*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2189-2207, 2024, DOI:10.32604/phyton.2024.055053 - 30 September 2024

Abstract Heavy metal contamination in the environment, resulting from human activities or natural processes, poses a significant and widespread challenge. L-glutamic (L-glu) and L-aspartic acid (L-asp) treatments have been reported to improve plant metabolism of heavy metal-exposed plants, but the role of these amino acids in the resistance to lead (Pb²⁺), cadmium (Cd²⁺), arsenic (As³⁺) and nickel (Ni²⁺) treated-bean are unclear when applied together. This study investigated the L-glu and L-asp supplementation-induced changes in some physio-biochemical parameters and some stress-related gene expression levels in Pb²⁺, Cd²⁺, As³⁺, and Ni²⁺-stressed Phaseolus vulgaris (Elkoca and Gina) grown in nutrient solution. The combination of… More >

Yanfei Feng, Jiaming Lin, Longxing Niu, Peng Pan, Xueping Liu, Linling Huang, Ying Guo, Mingzhong Li^*

Journal of Renewable Materials, Vol.11, No.1, pp. 167-184, 2023, DOI:10.32604/jrm.2022.021339 - 10 August 2022

Abstract The development of a method for the quantitative determination of the sericin content ratio (SCR) is urgently needed for silk refining and the purification of silk fibroin for biomedical applications. In this work, a series of sericin/fibroin mixed samples with known SCRs were prepared by mixing initial samples of extracted sericin and fibroin from Bombyx mori silk. Significant differences were found in the contents of characteristic hydrophilic amino acids abundant in sericin and hydrophobic amino acids abundant in fibroin, and several linear relationships of SCR associated with the content ratios of Ser/Ala, Asp/Ala, Lys/Ala, Asp/Gly and… More > Graphic Abstract

Talha Imtiaz Baig^1,*, Yaser Daanial Khan¹, Talha Mahboob Alam², Bharat Biswal³, Hanan Aljuaid⁴, Durdana Qaiser Gillani⁵

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 215-230, 2022, DOI:10.32604/cmc.2022.021849 - 03 November 2021

Abstract Lysine Lipoylation is a protective and conserved Post Translational Modification (PTM) in proteomics research like prokaryotes and eukaryotes. It is connected with many biological processes and closely linked with many metabolic diseases. To develop a perfect and accurate classification model for identifying lipoylation sites at the protein level, the computational methods and several other factors play a key role in this purpose. Usually, most of the techniques and different traditional experimental models have a very high cost. They are time-consuming; so, it is required to construct a predictor model to extract lysine lipoylation sites. This… More >

Ahmed S. Sakr¹, M. Y. Shams², Amena Mahmoud³, Mohammed Zidan^4,*

CMC-Computers, Materials & Continua, Vol.70, No.1, pp. 123-134, 2022, DOI:10.32604/cmc.2022.019455 - 07 September 2021

Abstract In this new information era, the transfer of data and information has become a very important matter. Transferred data must be kept secured from unauthorized persons using cryptography. The science of cryptography depends not only on complex mathematical models but also on encryption keys. Amino acid encryption is a promising model for data security. In this paper, we propose an amino acid encryption model with two encryption keys. The first key is generated randomly using the genetic algorithm. The second key is called the protein key which is generated from converting DNA to a protein… More >