Chih-Hsin Hsu1,2, Jun-Neng Roan1,3, Jieh-Neng Wang4, Chien-Chi Huang5, Chao-Jung Shih3, Jyh-Hong Chen2,6, Jing-Ming Wu4, Chen-Fuh Lam7,8
Congenital Heart Disease, Vol.12, No.4, pp. 533-539, 2017, DOI:10.1111/chd.12479
Abstract Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling.
We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction.
Design: This prospective cohort study included 37 patients who were admitted for an occluder
implantation. Blood samples were collected before and after the procedure. We determined the
number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations.
Daily performance and cardiothoracic ratio were reevaluated later.
Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic
peptide levels. The cardiothoracic ratio and daily performance… More >
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