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  • Open Access


    Realization of Deep Learning Based Embedded Soft Sensor for Bioprocess Application

    V. V. S. Vijaya Krishna1,*, N. Pappa1, S. P. Joy Vasantharani2

    Intelligent Automation & Soft Computing, Vol.32, No.2, pp. 781-794, 2022, DOI:10.32604/iasc.2022.022181

    Abstract Industries use soft sensors for estimating output parameters that are difficult to measure on-line. These parameters can be determined by laboratory analysis which is an offline task. Now a days designing Soft sensors for complex nonlinear systems using deep learning training techniques has become popular, because of accuracy and robustness. There is a need to find pertinent hardware for realizing soft sensors to make it portable and can be used in the place of general purpose PC. This paper aims to propose a new strategy for realizing a soft sensor using deep neural networks (DNN)… More >

  • Open Access


    In Vitro Propagation of Agave guiengola Gentry Using Semisolid Medium and Temporary Immersion Bioreactors

    Lucía Isabel Chávez-Ortiz1, José Francisco Morales-Domínguez1, Araceli Rodríguez-Sahagún2, Eugenio Pérez-Molphe-Balch1,*

    Phyton-International Journal of Experimental Botany, Vol.90, No.3, pp. 1003-1013, 2021, DOI:10.32604/phyton.2021.012862

    Abstract Agave guiengolaGentry is an endemic plant from a very small locality in Oaxaca, Mexico. Its conservation status is fragile and can rapidly worsen. Because of its scarcity, this agave has been used solely for ornamental purposes, but it could have other uses if more plants were available. In vitro propagation by enhanced axillary sprouting from stem segments was attained using Murashige and Skoog Basal Medium (MS) as well as basal medium supplemented with cytokinins 6-Benzylaminopurine (BA) or 6-(γ,γ-Dimethylallylamino)purine (2iP). The best treatment for shoot induction in semisolid medium consisted in MS supplemented with 2 mg l–1 BA, obtaining… More >

  • Open Access


    Hepatocyte culture in a radial-flow bioreactor with plasma polypyrrole coated scaffolds


    BIOCELL, Vol.39, No.2-3, pp. 9-14, 2015, DOI:10.32604/biocell.2015.39.009

    Abstract We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated scaffold. We designed a culture chamber where a radial flow of culture medium was continuously delivered through it. Once this system was established, flow was simulated using flow dynamics software based on numeric methods to solve Navier-Stockes flow equations. Perfusion within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor chamber. Afterwards, the bioreactor was built according to the simulated design More >

  • Open Access


    Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment

    Odin RAMÍREZ-FERNÁNDEZ1,2,3,*, Ludovika CACOPARDO1, Benjamín LEON-MANCILLA2, Joana COSTA1

    BIOCELL, Vol.43, No.1, pp. 29-36, 2019, DOI:10.32604/biocell.2019.04790

    Abstract We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy More >

  • Open Access


    Fluid Dynamics of a Micro-Bioreactor for Tissue Engineering

    P. Yu1, T. S. Lee1, Y. Zeng1, H. T. Low2

    FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.3, pp. 235-246, 2005, DOI:10.3970/fdmp.2005.001.235

    Abstract A numerical model is developed for the investigation of flow field and mass transport in a micro-bioreactor, of working volume below 5 ml, in which medium mixing is generated by a magnetic stirrer-rod rotating on the bottom. The flow-field results show that a recirculation region exists above the stirrer rod and rotates with it; the related fluid mixing is characterized by a circulation coefficient of up to 0.2 which is about five times smaller than that of a one-litre stirred-tank bioreactor. The oxygen transfer coefficient is less than 5 h-1 which is two orders smaller than… More >

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