Jan Hinnerk Hansen1, Lydia Kissner1, Jana Logoteta1, Olaf Jung1, Peter Dütschke2, Tim Attmann3, Jens Scheewe3, Hans‐Heiner Kramer1,4
Congenital Heart Disease, Vol.14, No.3, pp. 427-437, 2019, DOI:10.1111/chd.12741
Abstract Objectives: Neonates and infants undergoing surgery for congenital heart disease
are at risk for developmental impairment. Hypoxic‐ischemic brain injury might be one
contributing factor. We aimed to investigate the perioperative release of the astro‐
cyte protein S100B and its relation to cerebral oxygenation.
Methods: Serum S100B was measured before and 0, 12, 24, and 48 hours after sur‐
gery. Cerebral oxygen saturation was derived by near‐infrared spectroscopy. S100B
reference values based on preoperative samples; concentrations above the 75th per‐
centile were defined as elevated. Patients with elevated S100B at 24 or 48 hours
were compared to cases with S100B in… More >
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