KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

S. Kannan^1,*, S. Anusuya²

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3835-3851, 2023, DOI:10.32604/cmc.2023.042465

Abstract Gliomas, the most prevalent primary brain tumors, require accurate segmentation for diagnosis and risk assessment. In this paper, we develop a novel deep learning-based method, the Dynamic Hierarchical Attention for Improved Segmentation and Survival Prognosis (DHA-ISSP) model. The DHA-ISSP model combines a three-band 3D convolutional neural network (CNN) U-Net architecture with dynamic hierarchical attention mechanisms, enabling precise tumor segmentation and survival prediction. The DHA-ISSP model captures fine-grained details and contextual information by leveraging attention mechanisms at multiple levels, enhancing segmentation accuracy. By achieving remarkable results, our approach surpasses 369 competing teams in the 2020 Multimodal Brain Tumor Segmentation Challenge. With… More >

Tawfeeq Shawly¹, Ahmed Alsheikhy^2,*

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 425-443, 2023, DOI:10.32604/cmc.2023.040561

Abstract According to the World Health Organization (WHO), Brain Tumors (BrT) have a high rate of mortality across the world. The mortality rate, however, decreases with early diagnosis. Brain images, Computed Tomography (CT) scans, Magnetic Resonance Imaging scans (MRIs), segmentation, analysis, and evaluation make up the critical tools and steps used to diagnose brain cancer in its early stages. For physicians, diagnosis can be challenging and time-consuming, especially for those with little expertise. As technology advances, Artificial Intelligence (AI) has been used in various domains as a diagnostic tool and offers promising outcomes. Deep-learning techniques are especially useful and have achieved… More >

Ibrahim Mahmoud El-Henawy¹, Mostafa Elbaz², Zainab H. Ali^3,*, Noha Sakr⁴

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3489-3502, 2023, DOI:10.32604/cmc.2023.033356

Abstract Medical image segmentation is a crucial process for computer-aided diagnosis and surgery. Medical image segmentation refers to portioning the images into small, disjointed parts for simplifying the processes of analysis and examination. Rician and speckle noise are different types of noise in magnetic resonance imaging (MRI) that affect the accuracy of the segmentation process negatively. Therefore, image enhancement has a significant role in MRI segmentation. This paper proposes a novel framework that uses 3D MRI images from Kaggle and applies different diverse models to remove Rician and speckle noise using the best possible noise-free image. The proposed techniques consider the… More >

Hiba Alzoubi¹, Alameen Alsabbah², Rosario Caltabiano³, Giuseppe Broggi^3,*

Oncologie, Vol.24, No.1, pp. 51-63, 2022, DOI:10.32604/oncologie.2022.020890

Abstract The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) improved our understanding of the brain neoplasm biology. In more details, differences between diffuse gliomas that primarily occur in adults and those that primarily occur in children have been identified by the terms “adult-type” and “pediatric-type” diffuse gliomas. More importantly, both diagnostic and grading criteria for adult-type diffuse astrocytomas have been modified, by adopting novel molecular markers: diffuse astrocytomas, IDH-mutant have been grouped into a single entity and graded as CNS WHO grades 2, 3, or 4, with the assignment of Grade 4 in the… More >

T. Jeslin^1,*, J. Arul Linsely²

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 171-182, 2022, DOI:10.32604/cmc.2022.020255

Abstract Brain cancer is the premier reason for cancer deaths all over the world. The diagnosis of brain cancer at an initial stage is mediocre, as the radiologist is ineffectual. Different experiments have been conducted and demonstrated clearly that the algorithms for nodule segmentation are unsuccessful. Therefore, the research has consolidated incremental clustering focused on superpixel segmentation as an appropriate optimization approach for the accurate segmentation of pulmonary nodules. The key aim of the research is to refine brain CT images to accurately distinguish tumors and the segmentation of small-scale anomalous nodules in the brain region. In the beginning stage, an… More >