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Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*

1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India
2 Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58, Delhi-Roorkee Highway, Meerut, 250005, India
3 Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, 136119, India
4 Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, 127021, India
5 MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India
6 Delhi Pharmaceutical Sciences and Research University (DIPSAR), Delhi Pharmaceutical Sciences and Research University, New Delhi, 110017, India

* Corresponding Authors: RAKESH PAHWA. Email: email; DEEPAK KAUSHIK. Email: email

Oncology Research 2024, 32(5), 877-897. https://doi.org/10.32604/or.2024.047278

Abstract

Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases, for example, PubMed, Science Direct, Google Scholar, and others, using specific keyword combinations, including “glioblastoma,” “brain tumor,” “nanocarriers,” and several others. Conclusion: This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

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Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

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APA Style
WADHWA, K., CHAUHAN, P., KUMAR, S., PAHWA, R., VERMA, R. et al. (2024). Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier. Oncology Research, 32(5), 877-897. https://doi.org/10.32604/or.2024.047278
Vancouver Style
WADHWA K, CHAUHAN P, KUMAR S, PAHWA R, VERMA R, GOYAL R, et al. Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier. Oncol Res. 2024;32(5):877-897 https://doi.org/10.32604/or.2024.047278
IEEE Style
K. WADHWA et al., "Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier," Oncol. Res., vol. 32, no. 5, pp. 877-897. 2024. https://doi.org/10.32604/or.2024.047278



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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