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Underlying mechanisms and clinical potential of circRNAs in glioblastoma

LEI ZHANG*, YUAN ZHANG, HUIJUAN GAO, XIN LI, PEIFENG LI*

Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266021, China

* Corresponding Authors: LEI ZHANG. Email: email; PEIFENG LI. Email: email

Oncology Research 2023, 31(4), 449-462. https://doi.org/10.32604/or.2023.029062

Abstract

Glioblastoma (GBM) is the most malignant form of glioma and is difficult to diagnose, leading to high mortality rates. Circular RNAs (circRNAs) are noncoding RNAs with a covalently closed loop structure. CircRNAs are involved in various pathological processes and have been revealed to be important regulators of GBM pathogenesis. CircRNAs exert their biological effects by 4 different mechanisms: serving as sponges of microRNAs (miRNAs), serving as sponges of RNA binding proteins (RBPs), modulating parental gene transcription, and encoding functional proteins. Among the 4 mechanisms, sponging miRNAs is predominant. Their good stability, broad distribution and high specificity make circRNAs promising biomarkers for GBM diagnosis. In this paper, we summarized the current understanding of the characteristics and action mechanisms of circRNAs, illustrated the underlying regulatory mechanisms of circRNAs in GBM progression and explored the possible diagnostic role of circRNAs in GBM.

Graphical Abstract

Underlying mechanisms and clinical potential of circRNAs in glioblastoma

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APA Style
ZHANG, L., ZHANG, Y., GAO, H., LI, X., LI, P. (2023). Underlying mechanisms and clinical potential of circrnas in glioblastoma. Oncology Research, 31(4), 449-462. https://doi.org/10.32604/or.2023.029062
Vancouver Style
ZHANG L, ZHANG Y, GAO H, LI X, LI P. Underlying mechanisms and clinical potential of circrnas in glioblastoma. Oncol Res. 2023;31(4):449-462 https://doi.org/10.32604/or.2023.029062
IEEE Style
L. ZHANG, Y. ZHANG, H. GAO, X. LI, and P. LI "Underlying mechanisms and clinical potential of circRNAs in glioblastoma," Oncol. Res., vol. 31, no. 4, pp. 449-462. 2023. https://doi.org/10.32604/or.2023.029062



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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