Seul Gi Cha1, Mi Kyung Song1, Sang Yun Lee1, Gi Beom Kim1, Jae Gun Kwak2, Woong Han Kim2, Eun Jung Bae1
Congenital Heart Disease, Vol.14, No.5, pp. 684-690, 2019, DOI:10.1111/chd.12810
Abstract Objective: Cardiovascular lesions are the leading cause of morbidity and mortality in
patients with Williams syndrome. Recent studies have rebutted conventional reports
about the natural course of cardiovascular anomalies in Williams syndrome.
Design: Retrospective study.
Setting: Single tertiary center.
Patients: Eighty patients with Williams syndrome followed up for more than 5 years.
Interventions: Not applicable.
Outcome Measures: Long‐term outcome of cardiovascular lesions, peak velocity
change in obstructive cardiovascular lesions over time, post‐interventional courses
of disease‐specific intervention, and intervention‐free survival of obstructive cardio‐
vascular lesions.
Results: The median follow‐up duration was 11.0 (5.1‐28.3) years. Among 80 pa‐
tients, supravalvular aortic stenosis… More >
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