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  • Open Access


    3D Bio-Plotted Tricalcium Phosphate/Zirconia Composite Scaffolds to Heal Large Size Bone Defects

    Pranav S. Sapkal1,*, Abhaykumar M. Kuthe1, Shantanu Mathankar2, Akash A. Deshmukh

    Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 125-136, 2017, DOI:10.3970/mcb.2017.014.123

    Abstract β-TCP-Zirconia scaffolds with different architectures were fabricated by means of 3D-Bioplotting in order to enhance the mechanical and in-vitro ability of the scaffold to heal large size bone defects. In the present study scaffold architecture with different strand orientations (0°-90°, 0°-45°-135°-180°, 0°-108°-216° and 0°-72°-144°-36°-108°) were fabricated, characterized and evaluated for mechanical strength and cell proliferation ability. β-TCP powder (25 µm) and PVA (Polyvinyl Alcohol) was acquired from Fisher Scientific, India. Zirconia (18 to 32 µm) was procured from Lobachemie, India. In brief 7.5%, PVA in distilled water was used as a binder and was mixed… More >

  • Open Access


    Differential Responses of Cultured MC3T3-E1 Cells to Dynamic and Static Stimulated Effect of Microgravity in Cell Morphology, Cytoskeleton Structure and Ca2+ Signaling

    Mingzhi Luo1,2, Peili Yu1, Yang Jin3, Zhili Qian1, Yue Wang1, Jingjing Li1, Peng Shang2*, Linhong Deng1*

    Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 137-157, 2016, DOI:10.3970/mcb.2016.013.155

    Abstract Random positioning machine (RPM) and diamagnetic levitation are two essential ground-based methods used to stimulate the effect of microgravity in space life science research. However, the force fields generated by these two methods are fundamentally different, as RPM generates a dynamic force field acting on the surface in contact with supporting substrate, whereas diamagnetic levitation generates a static force field acting on the whole body volume of the object (e.g. cell). Surprisingly, it is hardly studied whether these two fundamentally different force fields would cause different responses in mammalian cells. Thus we exposed cultured MC3T3-E1… More >

  • Open Access


    3D Bio-Plotted Composite Scaffold Made of Collagen Treated Hydroxyapatite-Tricalciumphosphate for Rabbit Tibia Bone Regeneration

    Pranav S. Sapkal1*, Abhaykumar M. Kuthe1, Divya Ganapathy2, Shantanu C. Mathankar3, Sudhanshu Kuthe4

    Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 115-136, 2016, DOI:10.3970/mcb.2016.013.131

    Abstract Biphasic calcium phosphate scaffolds with 20/80 HA/TCP ratio were fabricated using the 3D-Bioplotting system to heal critical size defects in rabbit tibia bone. Four different architectures were printed in a layer by layer fashion with lay down patterns viz. (a) 0°– 90°, (b) 0°– 45°– 90°– 135°, (c) 0°–108°– 216° and (d) 0°– 60°– 120°. After high-temperature sintering scaffolds were coated with collagen and were further characterized by (FTIR) Fourier Transform Infrared Spectroscopy, (SEM) Scanning Electron Microscopy, (XRD) X-Ray diffraction, Porosity analysis and Mechanical testing. Scaffold samples were tested for its ability to induce cytotoxicity… More >

  • Open Access


    Intracellular Calcium Waves in Bone Cell Networks under Single Cell Nanoindentation

    X. Edward Guo∗,†,‡, Erica Takai∗,‡, Xingyu Jiang§, Qiaobing Xu§, George M. Whitesides§, James T. Yardley, Clark T. Hung*, Eugene M. Chow||, Thomas Hantschel∗∗, Kevin D. Costa

    Molecular & Cellular Biomechanics, Vol.3, No.3, pp. 95-108, 2006, DOI:10.3970/mcb.2006.003.095

    Abstract In this study, bone cells were successfully cultured into a micropatterned network with dimensions close to that of in vivo osteocyte networks using microcontact printing and self-assembled monolyers (SAMs). The optimal geometric parameters for the formation of these networks were determined in terms of circle diameters and line widths. Bone cells patterned in these networks were also able to form gap junctions with each other, shown by immunofluorescent staining for the gap junction protein connexin 43, as well as the transfer of gap-junction permeable calcein-AM dye. We have demonstrated for the first time, that the intracellular More >

  • Open Access


    Birefringence Simulations of Calcium Fluoride Single Crystal Used as Chamber Window of Gas Laser Light Source

    Yuta Kitamura1, Noriyuki Miyazaki1, Takahito Kumazaki2, Naoto Nagakura3, Yasuhiro Hashimoto3, Isao Masada3

    CMES-Computer Modeling in Engineering & Sciences, Vol.68, No.2, pp. 151-166, 2010, DOI:10.3970/cmes.2010.068.151

    Abstract CaF2 single crystal is used as high performance optical elements. We developed an analysis system for simulating birefringence of CaF2 single crystal used as a chamber window of a gas laser light source. The analysis system consists of a stress analysis and a birefringence analysis. In the stress analysis, the finite element method was applied to obtain the mechanical stress caused by a window holder and gas pressure. In the birefringence analysis, the photo-elastic effect gives the change of refractive indices, from which the optical path difference and the fast axis are calculated by using the More >

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