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    ARTICLE

    Deep-piRNA: Bi-Layered Prediction Model for PIWI-Interacting RNA Using Discriminative Features

    Salman Khan1, Mukhtaj Khan1,2, Nadeem Iqbal1, Mohd Amiruddin Abd Rahman3,*, Muhammad Khalis Abdul Karim3

    CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 2243-2258, 2022, DOI:10.32604/cmc.2022.022901

    Abstract Piwi-interacting Ribonucleic acids (piRNAs) molecule is a well-known subclass of small non-coding RNA molecules that are mainly responsible for maintaining genome integrity, regulating gene expression, and germline stem cell maintenance by suppressing transposon elements. The piRNAs molecule can be used for the diagnosis of multiple tumor types and drug development. Due to the vital roles of the piRNA in computational biology, the identification of piRNAs has become an important area of research in computational biology. This paper proposes a two-layer predictor to improve the prediction of piRNAs and their function using deep learning methods. The proposed model applies various feature… More >

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