VITTORIO PICCHIO¹, FRANCESCA PAGANO², ISOTTA CHIMENTI^1,3,*

BIOCELL, Vol.46, No.8, pp. 1875-1877, 2022, DOI:10.32604/biocell.2022.020181

Abstract Cardiac stromal cells have faced through the years a significant evolution in their definitions concerning their phenotypes, markers, and functions. They are surging to key roles in physiopathology, becoming important targets to be exploited for cardiac repair. In this perspective, we briefly discuss their role in novel therapeutic strategies for enhancing cardiac repair and regeneration. More >

Omnia Shafei^1,2,*, Alyaa A. Kotby^1,2, Mona M. El Ganzoury^1,2, Nevin M. Habeeb^1,2, Eman Elsayed^1,2

Congenital Heart Disease, Vol.17, No.2, pp. 173-185, 2022, DOI:10.32604/CHD.2021.016987

Abstract Objectives: We aimed to evaluate the effect of percutaneous atrial septal defect (ASD) closure in children using right heart indices and serum galectin-3 (Gal-3), as potential biomarkers of right heart remodeling. Methods: This case–control prospective study included 40 children with ASD and 25 control subjects. An echocardiographic evaluation was performed before the procedure, as well as 24 h, 1 month, and 6 months after intervention. Serum Gal-3 was measured before, and 1 month after the procedure. Results: Serum Gal-3 concentration, right atrial (RA) dimensions, right ventricular (RV) dimensions, indexed RA area, and right index of myocardial performance (RIMP) were significantly… More >

Geena Kim¹, Hong Ryang Kil^2,*

Congenital Heart Disease, Vol.16, No.3, pp. 211-220, 2021, DOI:10.32604/CHD.2021.013724

Abstract Background: The influence of the timing of transcatheter atrial septal defect (ASD) closure on ventricular remodeling at 6 months after ASD closure is unclear. This study investigated changes in cardiac remodeling after transcatheter closure of large ASDs according to patient age at the time of the procedure. Methods: In this study, 41 children and 43 adults underwent percutaneous closure of a large ASD. Cardiac remodeling was assessed by two-dimensional echocardiography and electrocardiography before and at 6 months after ASD closure. Results: The age of the children and adults were 2.8 ± 3.1 and 50.0 ± 15.6 years, respectively. The Qp/Qs… More >

Koert de Waal¹, Nilkant Phad¹, Nick Collins², Andrew Boyle²

Congenital Heart Disease, Vol.12, No.3, pp. 364-372, 2017, DOI:10.1111/chd.12454

Abstract Background: Sustained volume load due to a patent ductus arteriosus (PDA) leads to cardiac remodeling. Remodeling changes can become pathological and are associated with cardiovascular disease progression. Data on remodeling changes in preterm infants is not available.
Methods: Clinical and echocardiography data were collected in preterm infants <30 weeks gestation on postnatal day 3 and then every 7–14 days until closure of the ductus arteriosus. Images were analyzed using conventional techniques and speckle tracking. Remodeling changes of infants with prolonged (>14 days) exposure to a PDA were compared to control infants without a PDA.
Results: Thirty out of 189 infants… More >

Yufan Huang¹, Pei Niu², Li Li², Yunlong Huo^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 47-47, 2019, DOI:10.32604/mcb.2019.05726

Abstract We aimed to illustrate the association between short-term exposure PM0.1 and heart failure in myocardial infarction (MI) mice. Six-week-old ICR mice were divided into three groups randomly: sham group, MI group and MI exposure group, 12 mice in each group. LAD ligation operation was performed in MI group and MI exposure group. After postoperative two weeks MI exposure mice were put into ventilation chamber which filled with 500 ug/m³ PM_0.1 for 6 hours per day, while MI group mice and sham group mice were cultivated in normal environment. After exposure 8 weeks, we use Vevo 2100 machine to acquire heart… More >