Yaru Zhu1,2,3, Xiujun Zhang1, Yansheng Zhang3, Shiyou Lü1,4,*, Changfu Li1,3,*
Phyton-International Journal of Experimental Botany, Vol.91, No.2, pp. 279-291, 2022, DOI:10.32604/phyton.2022.017625
Abstract Tripterygium wilfordii has been renowned mostly because of the anticancer effects of its root extracts, which is partly ascribed to the presence of celastrol, a pentacyclic triterpenoid, as one of the main active components. Celastrol also has recently been reported as an effective prodrug in the treatment of obesity. Despite the promising activities, the pathway leading to celastrol biosynthesis, especially cytochrome P450 (CYP) enzyme(s) that occur in its downstream steps, are largely unknown. This study conducted a comparative analysis of the T. wilfordii transcriptome derived from its root and leaf tissues. Differential gene expression analysis identified a number of root-specific… More >
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