LI KAILONG1,2, DU XIAOLAN1, HE YANI2, ZHAO LIN1, YANG JVRONG2, SONG RUIHUA1, CHEN LIN1
BIOCELL, Vol.31, No.2, pp. 213-223, 2007, DOI:10.32604/biocell.2007.31.213
Abstract Objective: To investigate the course of tubular cell senescence and expressions of p53, p21,
and Rb during the late phase of ischemia/reperfusion (IRI) in the kidney, and assess the effects of the p53-Rb
pathway on tubular cell senescence. Methods: Experimental models of unilateral renal IRI were used in
p53(+/+) and p53(-/-) mice. Histological changes at the tubular level, progress of cell senescence, and the
expression of Rb, p21, and/or p53 proteins in tubular cells were studied at different moments in time after
IRI. Results: Chronic tubulointerstitial fibrosis was much more severe and widely distributed in IRI kidneys
of p53(+/+) mice… More >
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