Peter M. Pinsky*
CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.3, pp. 1329-1350, 2021, DOI:10.32604/cmes.2021.017740
Abstract A fundamental problem for cells with their fragile membranes is the control of their volume. The primordial
solution to this problem is the active transport of ions across the cell membrane to modulate the intracellular
osmotic pressure. In this work, a theoretical model of the cellular pump-leak mechanism is proposed within the
general framework of linear nonequilibrium thermodynamics. The model is expressed with phenomenological
equations that describe passive and active ionic transport across cell membranes, supplemented by an equation for
the membrane potential that accounts for the electrogenicity of the ionic pumps. For active ionic transport, the
model predicts that… More >
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