Flavia Oliveira Monteiro da Silva Abreu^1,2,*, Taysse Holanda¹, Joice Farias do Nascimento¹, Henety Nascimento Pinheiro¹, Rachel Menezes Castelo¹, Hélcio Silva dos Santos³, Thais Benincá⁴, Patrícia da Silva Malheiros⁴, Júlio César Sousa Prado⁵, Raquel de Oliveira Fontenelle⁵, Maria Madalena de Camargo Forte²

Journal of Renewable Materials, Vol.12, No.2, pp. 285-304, 2024, DOI:10.32604/jrm.2023.043919

Abstract With the increase in antimicrobial resistance, it has become necessary to explore alternative approaches for combating and preventing diseases. DB-cinnamaldehyde (CNM) and Benzyl4-amino (B4AM) are bioactive compounds derived from chalcones but with restricted solubility in aqueous media. Nanoemulsions can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials, with reduced side effects and prolonged release. The objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages, to propose a stable formulation with antimicrobial properties. Results showed that nanoemulsions presented… More > Graphic Abstract

MARÍA DE LOS ANGELES ALVAREZ, VALERIA E. P. ZARELLI, NORA B.PAPPANO, NORA B. DEBATTISTA

BIOCELL, Vol.28, No.1, pp. 31-34, 2004, DOI:10.32604/biocell.2004.28.031

Abstract In previous work the bacteriostatic action of trihydroxylated chalcones against Staphylococcus aureus ATCC 25 923 was investigated. In this work the action of 2´, 4´, 2-(OH)₃ -chalcone, 2´, 4´, 3-(OH)_3^- chalcone and 2´, 4´, 4-(OH)₃ –chalcone against Escherichia coli ATCC 25 922 was evaluated. Growth kinetic curves of E.coli were made in nutritive broth added with increasing drug concentrations. The specific growth rates of the microorganisms were calculated by a kinetic turbidimetric method, which was previously probed and the minimal inhibitory concentrations (MIC´s) were evaluated by a mechanism of action proposed. The MICs of 2´, 4´, 3-(OH)₃ -chalcone and 2´,… More >