MIN SHEN1,2, XIAOMAN XU1,2, GUANGLING SUN1, LIANGZHU WANG1, TAO YING1, HANG SU1, WEI WANG1, QINGHUA CAO1,*, ZHEZHE SUN1,*
BIOCELL, Vol.48, No.3, pp. 491-499, 2024, DOI:10.32604/biocell.2023.047640
Abstract Objective: Circular RNAs (circRNAs) have been shown to involve in pathological processes of ischemic stroke (IS), including autophagy. This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms. Methods: Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected. Hippocampal neurons were treated with oxygen and glucose deprivation (OGD) to establish IS in vitro model. The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope. Cell apoptosis rate… More >
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