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    Aortic stenting in the growing sheep causes aortic endothelial dysfunction but not hypertension: Clinical implications for coarctation repair

    Nicola Maschietto1, Luca Semplicini2, Giulio Ceolotto2, Arianna Cattelan2, Helen Poser3, Ilaria Iacopetti3, Gabriele Gerardi3, Giulia Maria De Benedictis3, Tommaso Pilla3, Daniele Bernardini3, Luca Aresu4, Stefania Rizzo5, Cristina Basso5, Andrea Semplicini2, Ornella Milanesi1

    Congenital Heart Disease, Vol.12, No.1, pp. 74-83, 2017

    Abstract Background: Stent implantation is the treatment of choice for adolescents and adults with aortic coarctation (CoAo). Despite excellent short-term results, 20%–40% of the patients develop arterial hypertension later in life, which was attributed to inappropriate response of the aortic baroreceptors to increased stiffness of the ascending aorta (ASAO), either congenital or induced by CoAo repair. In particular, it has been hypothesized that stent itself may cause or sustain hypertension. Therefore, we aimed to study the hemodynamic and structural impact following stent implantation in the normal aorta of a growing animal.
    Methods: Eight female sheep completed the study and a stent… More >

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