Alexander Lemmer1, Lisa VanWagner1,2, Zaira Gasanova3, Steve Helmke4,5, Gregory T. Everson4,5, Daniel Ganger1
Congenital Heart Disease, Vol.14, No.6, pp. 978-986, 2019, DOI:10.1111/chd.12831
Abstract Background & Aims: Fontan surgery for single ventricle congenital heart disease
leads to Fontan‐associated liver disease (FALD). Typical laboratory tests, imaging,
and histopathology cannot predict clinical severity in FALD. HepQuant SHUNT is
a proprietary serum test of hepatic function and physiology that has not yet been
evaluated in FALD.
Methods: Fourteen adult FALD patients at a single urban tertiary care center who
underwent a Fontan procedure in childhood received HepQuant SHUNT testing
between September 2015 and April 2018. The HepQuant SHUNT disease severity
index (DSI) assesses global liver function and physiology from systemic and portal
hepatic filtration rates (HFRs, clearances… More >
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