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    ARTICLE

    Adhesive Models to Understand the Sensitivity of Bio-Molecules to Environmental Signals

    Shaohua Chen*

    Molecular & Cellular Biomechanics, Vol.5, No.2, pp. 97-106, 2008, DOI:10.3970/mcb.2008.005.097

    Abstract Recently, contact mechanics has been widely used to get some understanding of the biological adhesion mechanisms, such as cell-cell adhesion, insects' adhesion and locomotion. JKR theory is usually adopted as a basis, in which the interaction of molecules is considered in contrast to the classical Hertz solution. In this paper, two problems are summarized, which may give some insights to cells or bio-molecules sensitivity to environmental signals: (1) cell reorientation on a stretched substrate; (2) spontaneous detachment between cells or bio-molecules under the variation of environmental signals. The intention here is only to illustrate the possibilities that contact mechanics may… More >

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