Dimitrije Stamenovic´ 1
Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 69-76, 2005, DOI:10.3970/mcb.2005.002.069
Abstract It is well established that adherent cells change their orientation in response to non-uniform substrate stretching. Most observations indicate that cells orient away from the direction of the maximal substrate strain, whereas in some cases cells also align with the direction of the maximal strain. Previous studies suggest that orientation and steering of the cell may be closely tied to cytoskeletal contractile stress but they could not explain the mechanisms that direct cell reorientation. This led us to develop a simple, mechanistic theoretical model that could predict a direction of cell orientation in response to mechanical nonuniformities of the substrate.… More >
Login
Register
