Liqiong Ding¹, Pingsheng Li², Liu He¹, Fengnan Xu¹, Jieqiong Ding^3,*, Binhua Luo^1,*

Journal of Renewable Materials, Vol.10, No.3, pp. 767-780, 2022, DOI:10.32604/jrm.2022.016903

Abstract The development of contrast agents that can be activated by multiple modes is of great significance for tumor diagnosis. In this study, the lactoferrin (Lf)-conjugated polylactic acid (PLLA) nanobubbles (Lf-PLLA NBs) were used to encapsulate liquid perfluoropentane (PFP) with the double emulsion method, creating PFP loaded (PFP/Lf-PLLA) NBs for the ultrasound/magnetic resonance dual-modality imaging of subcutaneous tumor. The particle diameter and stability of nanobubbles were investigated by photon correlation spectroscopy. The biocompatibility of nanobubbles was preliminarily evaluated by cell proliferation and migration assay, hemolysis rate, and blood biochemistry analysis. A B-mode clinical ultrasound real-time imaging system was used to perform… More >

Mo Hou^1,*, Weiyu Kevin Chiang^2,*, Weiqiang Hong¹, Maoyun Yang¹, Wenhua Yu^3,4

Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 165-178, 2020, DOI:10.32604/mcb.2020.010805

Abstract To achieve the image registration/fusion and perfect the quality of the integration, with dual modality contrast agent (DMCA), a novel multi-scale representation registration method between ultrasound imaging (US) and magnetic resonance imaging (MRI) is presented in the paper, and how DMCA influence on registration accuracy is chiefly discussed. Owing to US’s intense speckle noise, it is a tremendous challenge to register US with any other modality images. How to improve the algorithms for US processing has become the bottleneck, and in the short term it is difficult to have a breakthrough. In that case, DMCA is employed in both US… More >