Anita T. Cote1,2, Martin Hosking3, Christine Voss1,3, Derek G. Human3, George G. S. Sandor1,3, Kevin C. Harris1,3
Congenital Heart Disease, Vol.13, No.5, pp. 663-670, 2018, DOI:10.1111/chd.12629
Abstract Objective: Pediatric heart transplant recipients are at risk of posttransplant coronary
artery disease known as cardiac allograft vasculopathy (CAV), and also may develop
diastolic dysfunction. As CAV begins with a process of progressive intimal thickening,
these occult diffuse changes may be detected using optical coherence tomography
(OCT). We hypothesized that the development of CAV, as identified via OCT, may be
a mechanism of declining ventricular function. Accordingly, the purpose of this study
was to assess coronary artery intimal thickening and LV strain in children who have
undergone heart transplantation.
Methods: In 17 children, we analyzed OCT images for coronary intima… More >
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