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  • Open Access


    FFR-Guided PCI in a 17-Year-Old Patient after Arterial Switch Operation for D-Transposition of the Great Arteries

    Domenico Sirico1, Biagio Castaldi1,*, Giuseppe Tarantini2, Giovanni Di Salvo1

    Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863

    Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and history of Arterial Switch Operation. We report the case of a 17-year-old boy with anomalous origin of left circumflex artery from the right coronary artery, who underwent neonatal arterial switch operation and developed silent myocardial ischemia under stress on myocardial scintigraphy. Despite coronary angiogram and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure wire, demonstrated a severe reduction of coronary fractional flow reserve after pharmacologically induced hyperemia. Thus, the patient… More >

  • Open Access


    A Fast-Fractional Flow Reserve Simulation Method in A Patient with Coronary Stenosis Based on Resistance Boundary Conditions

    Wenxin Wang1,2, Dalin Tang2, Boyan Mao1, Bao Li1, Xi Zhao3, Jian Liu4, Youjun Liu1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 163-173, 2018, DOI: 10.31614/cmes.2018.04219

    Abstract Fractional flow reserve (FFR) is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory. The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery, which can evaluate the performance of vascular stenosis, based on resistance boundary conditions. A patient-specific 3-dimensional (3D) model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images. The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model. This study was performed by coupling the 3D… More >

  • Open Access


    Hemodynamics of Enhanced External Counterpulsation with Different Coronary Stenosis

    Sihan Chen1, Bao Li1, Haisheng Yang1, Jianhang Du2, Xiaoling Li2, Youjun Liu1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 149-162, 2018, DOI: 10.31614/cmes.2018.04133

    Abstract Enhanced external counterpulsation (EECP) is able to treat myocardial ischemia, which is usually caused by coronary artery stenosis. However, the underlying mechanisms regarding why this technique is effective in treating myocardial ischemia remains unclear and there is no patient-specific counterpulsation mode for different rates of coronary artery stenosis in clinic. This study sought to investigate the hemodynamic effect of varied coronary artery stenosis rates when using EECP and the necessity of adopting targeted counterpulsation mode to consider different rates of coronary artery stenosis. Three 3-dimensional (3D) coronary models with different stenosis rates, including 55% (Model 1), 65% (Model 2), and… More >

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