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  • Open Access

    ARTICLE

    Correlation of senescence-related gene FEN1 on neuroblastoma progression and cisplatin chemotherapy sensitivity

    YOUYANG HU1,#, YISHU LUO1,#, TIANYUE XIE1, YUEHUA CHEN1,2, JUN ZHAO1, WEICHAO JI3, ZHIWEI YAN3, SITONG QIU3, KEXIN GAO3, HAIXIA ZHU4, LIMIN MA1,*, QIYOU YIN1,*

    Oncology Research, Vol.33, No.7, pp. 1695-1708, 2025, DOI:10.32604/or.2025.060021 - 26 June 2025

    Abstract Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy. Methods: Gene expression profiles and clinical data were obtained for 498 NB patients from the GEO database (GSE49710). The study focused on identifying genes that were… More >

  • Open Access

    SHORT COMMUNICATION

    A Gel-Free Budget-Friendly Approach to GFP-Tagged Viruses Quantification in Plant Samples

    Rohith Grandhi, Mélodie B. Plourde, Aditi Balasubramani, Hugo Germain*

    Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1497-1504, 2025, DOI:10.32604/phyton.2025.063974 - 29 May 2025

    Abstract Viral diseases are an important threat to crop yield, as they are responsible for losses greater than US$30 billion annually. Thus, understanding the dynamics of virus propagation within plant cells is essential for devising effective control strategies. However, viruses are complex to propagate and quantify. Existing methodologies for viral quantification tend to be expensive and time-consuming. Here, we present a rapid cost-effective approach to quantify viral propagation using an engineered virus expressing a fluorescent reporter. Using a microplate reader, we measured viral protein levels and we validated our findings through comparison by western blot analysis More >

  • Open Access

    ARTICLE

    Exploring the correlation and mechanism of natural killer cell cytotoxic sensitivity against gastric cancer

    WENZHUO YANG1,#, HAODONG CHEN2,#, ZHILAN ZHANG3, ZHIYONG XIA3, YUANYUAN JIN1,*, ZHAOYONG YANG1,*

    Oncology Research, Vol.33, No.6, pp. 1485-1494, 2025, DOI:10.32604/or.2025.059426 - 29 May 2025

    Abstract Background: Human natural killer (NK) cells have attracted widespread attention as a potential adoptive cell therapy (ACT). However, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. There is an urgent need to explore a suitable new treatment plan to overcome weaknesses and support the superior therapeutic activity of NK cells. Methods: In this study, the mechanisms underlying the susceptibility of gastric cancer (GC) cell lines AGS, HGC-27, and NCI-N87 to NK cell-mediated cytotoxicity were explored. Results: Lactic dehydrogenase (LDH) release assays showed that all three GC cell lines were susceptible… More >

  • Open Access

    ARTICLE

    A Tense Race: Correlation of Liver Stiffness with Ultrasound Elastography and Hemodynamics in Fontan Patients

    Yuen Lo Yau1, Matthew S. Purlee2, Lindsey M. Brinkley2, Dipankar Gupta1, David M. Saulino3, Dalia Lopez-Colon1, John-Anthony Coppola1, Dhanashree Rajderkar4, Himesh Vyas1,*

    Congenital Heart Disease, Vol.20, No.2, pp. 265-272, 2025, DOI:10.32604/chd.2025.065661 - 30 April 2025

    Abstract Background: Patients with Fontan physiology are predisposed to congestive hepatopathy, progressive liver fibrosis, and end-stage liver disease. Ultrasound-based shear wave elastography (SWE) is a non-invasive tool to diagnose and monitor liver fibrosis. We sought to determine whether the degree of hemodynamic derangement prior to and after the Fontan operation is associated with increased liver stiffness measured by SWE. Methods: A single-center retrospective study of patients with Fontan circulation who underwent ultrasound elastography between 2008 and 2024 was conducted. Liver stiffness was measured by SWE and reported as velocity in m/s. Hemodynamic assessment with cardiac catheterization and… More >

  • Open Access

    ARTICLE

    Semi-Supervised Medical Image Classification Based on Sample Intrinsic Similarity Using Canonical Correlation Analysis

    Kun Liu1, Chen Bao1,*, Sidong Liu2

    CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4451-4468, 2025, DOI:10.32604/cmc.2024.059053 - 06 March 2025

    Abstract Large amounts of labeled data are usually needed for training deep neural networks in medical image studies, particularly in medical image classification. However, in the field of semi-supervised medical image analysis, labeled data is very scarce due to patient privacy concerns. For researchers, obtaining high-quality labeled images is exceedingly challenging because it involves manual annotation and clinical understanding. In addition, skin datasets are highly suitable for medical image classification studies due to the inter-class relationships and the inter-class similarities of skin lesions. In this paper, we propose a model called Coalition Sample Relation Consistency (CSRC),… More >

  • Open Access

    ARTICLE

    Correlation Analysis of Power Quality and Power Spectrum in Wind Power Hybrid Energy Storage Systems

    Jian Gao1, Hongliang Hao2, Caifeng Wen1,*, Yongsheng Wang3, Zhanhua Han4, Edwin E. Nykilla2, Yuwen Zhang2

    Energy Engineering, Vol.122, No.3, pp. 1175-1198, 2025, DOI:10.32604/ee.2025.061083 - 07 March 2025

    Abstract Power quality is a crucial area of research in contemporary power systems, particularly given the rapid proliferation of intermittent renewable energy sources such as wind power. This study investigated the relationships between power quality indices of system output and PSD by utilizing theories related to spectra, PSD, and random signal power spectra. The relationship was derived, validated through experiments and simulations, and subsequently applied to multi-objective optimization. Various optimization algorithms were compared to achieve optimal system power quality. The findings revealed that the relationships between power quality indices and PSD were influenced by variations in More >

  • Open Access

    ARTICLE

    Correlation between Floral Color Attributes and Volatile Components among 10 Fragrant Phalaenopsis Cultivars

    Xiuyun Liu1, Jixia Sun2, Feng Ming3, Minxiao Liu2,*, Xinyu Wang2, Yingjie Zhang2,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 379-391, 2025, DOI:10.32604/phyton.2025.060726 - 06 March 2025

    Abstract To study the main aroma components of Phalaenopsis orchid and their relationship with colors, 10 fragrant cultivars with different colors, like pink, rose, yellow, and purple, were used as samples in this experiment. Headspace-gas chromatography-mass spectrometry was used to determine the main components of floral fragrance and analyze the correlation between floral color and fragrance. The results showed that the main aroma components of the 10 fragrant cultivars of Phalaenopsis were alcohols, alkenes, esters, and benzene ring compounds, and the main aroma components of different cultivars were diverse. The main aroma components of yellow fragrant flowers… More >

  • Open Access

    ARTICLE

    Evaluating Effect of Magnetic Field on Nusselt Number and Friction Factor of Fe3O4-TiO2/Water Nanofluids in Heat-Sink Using Artificial Intelligence Techniques

    L. S. Sundar*, Sérgio M. O. Tavares, António M. B. Pereira, Antonio C. M. Sousa

    Frontiers in Heat and Mass Transfer, Vol.23, No.1, pp. 131-162, 2025, DOI:10.32604/fhmt.2025.055854 - 26 February 2025

    Abstract The experimental analysis takes too much time-consuming process and requires considerable effort, while, the Artificial Neural Network (ANN) algorithms are simple, affordable, and fast, and they allow us to make a relevant analysis in establishing an appropriate relationship between the input and output parameters. This paper deals with the use of back-propagation ANN algorithms for the experimental data of heat transfer coefficient, Nusselt number, and friction factor of water-based Fe3O4-TiO2 magnetic hybrid nanofluids in a mini heat sink under magnetic fields. The data considered for the ANN network is at different Reynolds numbers (239 to 1874),… More >

  • Open Access

    ARTICLE

    Multi-Scenario Probabilistic Load Flow Calculation Considering Wind Speed Correlation

    Xueqian Wang*, Hongsheng Su

    Energy Engineering, Vol.122, No.2, pp. 667-680, 2025, DOI:10.32604/ee.2024.058102 - 31 January 2025

    Abstract As the proportion of new energy increases, the traditional cumulant method (CM) produces significant errors when performing probabilistic load flow (PLF) calculations with large-scale wind power integrated. Considering the wind speed correlation, a multi-scenario PLF calculation method that combines random sampling and segmented discrete wind farm power was proposed. Firstly, based on constructing discrete scenes of wind farms, the Nataf transform is used to handle the correlation between wind speeds. Then, the random sampling method determines the output probability of discrete wind power scenarios when wind speed exhibits correlation. Finally, the PLF calculation results of More >

  • Open Access

    REVIEW

    Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix

    RENATA DA SILVA CARNEIRO1, MATEUS HENRIQUE DE ALMEIDA DA COSTA1, JOSé ZILTON LIMA VERDE SANTOS1, VALDILéIA TEIXEIRA UCHôA2, LUCIANO DA SILVA LOPES3, ANDERSON NOGUEIRA MENDES1,*

    BIOCELL, Vol.49, No.1, pp. 109-125, 2025, DOI:10.32604/biocell.2024.058405 - 24 January 2025

    Abstract Neurodegenerative diseases are a major public health challenge, mainly affecting the elderly population and compromising their cognitive, sensory, and motor functions. Currently, available therapies focus on alleviating symptoms and slowing the progression of these conditions, but they do not yet offer a definitive cure. In this scenario, terpenes emerge as promising natural alternatives due to their neuroprotective properties. These compounds can reduce the formation of protein aggregates, neutralize free radicals, and inhibit pro-inflammatory enzymes, which are crucial factors in the development of neurodegenerative diseases. In addition, terpenes also play an important role in the… More >

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