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    Geometric Confinement Influences Cellular Mechanical Properties II -- Intracellular Variances in Polarized Cells

    Judith Su, Ricardo R. Brau, Xingyu Jiang, George M. Whitesides§, Matthew J. Lang, Peter T. C. So||

    Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 105-118, 2007, DOI:10.3970/mcb.2007.004.105

    Abstract During migration, asymmetrically polarized cells achieve motion by coordinating the protrusion and retraction of their leading and trailing edges, respectively. Although it is well known that local changes in the dynamics of actin cytoskeleton remodeling drive these processes, neither the cytoskeletal rheological properties of these migrating cells are well quantified nor is it understand how these rheological properties are regulated by underlying molecular processes. In this report, we have used soft lithography to create morphologically polarized cells in order to examine rheological differences between the front and rear zone of an NIH 3T3 cell posed for migration. In addition, we… More >

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