Aysenur Elmali¹, Birhan Demirhan², Caglayan Selenge Beduk Esen³, Ozan Cem Guler⁴, Pervin Hurmuz⁵, Cem Onal^1,4,*

Canadian Journal of Urology, Vol.32, No.4, pp. 243-254, 2025, DOI:10.32604/cju.2025.066700 - 29 August 2025

Abstract Background: Intermediate-risk prostate cancer (IR-PC) represents a heterogeneous group requiring nuanced treatment approaches, and recent advancements in radiotherapy (RT), androgen deprivation therapy (ADT), and prostate-specific membrane antigen positron emission tomography (PSMA-PET/CT) imaging have prompted growing interest in personalized, risk-adapted management strategies. This study by the Turkish Society for Radiation Oncology aims to examine radiation oncologists’ practices in managing IR-PC, focusing on RT and imaging modalities to identify trends for personalized treatments. Methods: A cross-sectional survey was conducted among Turkish radiation oncologists treating at least 50 prostate cancer (PC) cases annually. The 22-item questionnaire covered IR-PC… More >

Siliang Liu^1,#, Hong Tang^2,#, Ying Xia¹, Zhengtao Yu¹, Ning Gao^1,*

BIOCELL, Vol.49, No.7, pp. 1245-1264, 2025, DOI:10.32604/biocell.2025.064396 - 25 July 2025

Abstract Objectives: NOD-like receptor family pyrin domain-containing (NLRP) 1-mediated pyroptosis plays a key role in the pathogenesis of cerebral ischemia-reperfusion injury (CIRI). C-Myc is reported to play a major role in CIRI. However, the mechanism remains unclear. This study aimed to investigate whether c-Myc affects CIRI by regulating Serine/Arginine-rich Splicing Factor 1 (SRSF1)/NLRP1-mediated pyroptosis. Methods: Oxygen-glucose deprivation/reperfusion (OGD/R) induced neuroblastoma cells for the establishment of an in vitro CIRI model. The levels of c-Myc and SRSF1, cell viability, the expression of pyroptosis-related factors, and the interaction between SRSF1 and NLRP1 were evaluated. Results: The expression of c-Myc and… More >

Fanny Delehaye^1,2,*, Olivier Dejardin^1,3, Isabelle Pellier⁴, Ludivine Launay^1,5, Maxime Esvan⁶, Damien Bodet², Liana Carausu⁷, Julien Lejeune⁸, Frédéric Millot⁹, Caroline Thomas¹⁰, Virginie Gandemer¹¹, Arnaud Alves^1,12, Julien Rod^1,13

Psycho-Oncologie, Vol.18, No.2, pp. 117-126, 2024, DOI:10.32604/po.2024.043073 - 06 August 2024

Abstract La période post-traitement une part fondamental de la prise en charge du cancer pédiatrique. Durant cette période, les difficultés scolaires et psychologiques chez les survivants d’un cancer pédiatriques (SCP) sont connues et peuvent être pronostic sur la bonne réintégration sociale. Cette étude estime l’influence de la déprivation sociale du foyer de l’enfant sur ces difficultés. Notre étude se base sur une base de données multicentrique, et se concentre sur les SCP avant reçu une évaluation psychosociale au cours de leur suivi, de 2013 à 2020. Nous rapportons les données des difficultés scolaires et psychologiques. Le… More >

YANG GU^1,#,*, MINGGUANG BI^2,#, DEHUI CHEN³, NING NI⁴, JIANMING CHEN^1,*

BIOCELL, Vol.47, No.9, pp. 2069-2080, 2023, DOI:10.32604/biocell.2023.029989 - 28 September 2023

Abstract Background: The underlying mechanism of sciatic nerve injury (SNI) is a common motor functional disorder, necessitates further research. Methods: A rat model of SNI was established, with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical procedure. An oxygen-glucose deprivation model was employed to simulate in vitro SNI in PC12 cells. Following data acquisition and quality control, differentially expressed proteins (DEPs) in each model were identified through differential analysis, and enrichment analysis was used to explore the… More >

LOKMAN VARISLI^1,2, VEYSEL TOLAN¹, JIYAN H. CEN³, SPIROS VLAHOPOULOS⁴, OSMAN CEN^5,6,*

Oncology Research, Vol.30, No.3, pp. 137-155, 2022, DOI:10.32604/or.2022.026074 - 12 January 2023

Abstract Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing countries. Androgen deprivation therapy has been used as a standard treatment approach for advanced prostate cancer for more than 80 years. The primary aim of androgen deprivation therapy is to decrease circulatory androgen and block androgen signaling. Although a partly remediation is accomplished at the beginning of treatment, some cell populations become refractory to androgen deprivation therapy and continue to metastasize. Recent evidences suggest that androgen deprivation therapy may cause cadherin switching, from More >

RUICONG GUAN^1,3,#, KUAN ZENG^1,#, MINNAN GAO¹, JIANFEN LI¹, HUIQI JIANG¹, LU ZHANG¹, JINGWEN LI¹, BIN ZHANG¹, YUQIANG LIU¹, ZHUXUAN LIU¹, DIAN WANG¹, YANQI YANG^1,2,*

BIOCELL, Vol.46, No.11, pp. 2455-2463, 2022, DOI:10.32604/biocell.2022.021661 - 07 July 2022

Abstract Bone marrow mesenchymal stem cell (MSC)-based therapy is a novel candidate for heart repair. But ischemia-reperfusion injury leads to low viability of MSC. Dexmedetomidine (Dex) has been found to protect neurons against ischemia-reperfusion injury. It remains unknown if Dex could increase the viability of MSCs under ischemia. The present study is to observe the potential protective effect of Dex on MSCs under ischemia and its underlying mechanisms. Specific mRNAs related to myocardial ischemia in the GEO database were selected from the mRNA profiles assessed in a previous study using microarray. The most dysregulated mRNAs of… More >

JIANRONG YANG^1,#, WAN CHEN^2,#, XING ZHOU^3,#, YAOXUAN LI^4,#, ZHIHUANG NONG⁵, LIYUAN ZHOU⁴, XUAN WEI⁴, XIAORONG PAN⁶, CHUNXIA CHEN⁷, WENSHENG LU³

BIOCELL, Vol.46, No.1, pp. 137-148, 2022, DOI:10.32604/biocell.2022.016807 - 28 September 2021

Abstract In this study, we investigated the protective effect of hyperbaric oxygen (HBO) on PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion and its possible mechanism. PC12 and H9C2 cell oxygen-glucose deprivation/reperfusion model were established. Cells were divided into a control group, model group, hyperbaric air (HBA) group and HBO group. The cell viability was detected by the CCK8 assay. Hoechst 33342 and PI staining assays and mitochondrial membrane potential (MMP) assays were used to detect cell apoptosis. The ultrastructure of cells, including autophagosomes, lysosomes, and apoptosis, were examined using a transmission electron microscope. The… More >

Margaret E. Long¹, Andrew M. Vitale², Sarah L. Mott³, Chad Tracy², Rohan Garje³, Yousef Zakharia³, James A. Brown²

Canadian Journal of Urology, Vol.28, No.4, pp. 10738-10742, 2021

Abstract Introduction: Androgen deprivation therapy (ADT) is often used in the treatment of prostate cancer. Specific factors affecting testosterone recovery after cessation of ADT have not been well-characterized in existing literature.
Materials and methods: We retrospectively reviewed patients at our institution who received ADT between 1999 and 2018. Patients with at least one course of ADT and subsequent testosterone level within 12 months of cessation of ADT were included. Patients received at least one of the following four agents: leuprolide, goserelin, triptorelin, and degarelix. Cox regression models were utilized to estimate the effect of patient and treatment characteristics… More >

Richard J. Wassersug, John Robinson, R. Psych, Lauren Walker

Canadian Journal of Urology, Vol.25, No.6, pp. 9568-9568, 2018

Abstract This article has no abstract. More >

Sanae Haga^*, Takeaki Ozawa^†, Naoki Morita^‡, Mami Asano^§, Shigeki Jin^¶, Yimin^#, Michitaka Ozaki^*§¶

Oncology Research, Vol.26, No.3, pp. 467-472, 2018, DOI:10.3727/096504017X15040166233313

Abstract Akt is commonly overexpressed and activated in cancer cells and plays a pivotal role in cell survival, protection, and chemoresistance. Therefore, Akt is one of the target molecules in understanding characters of cancer cells and developing anticancer drugs. Here we examined whether a newly developed photo-activatable Akt (PA-Akt) probe, based on a light-inducible protein interaction module of plant cryptochrome2 (CRY2) and cryptochrome-interacting basic helix–loop–helix (CIB1), can regulate Akt-associated cell functions. By illuminating blue light to the cells stably transfected with PA-Akt probe, CRY2-Akt (a fusion protein of CRY2 and Akt) underwent a structural change and… More >