Marziyeh Eftekhari¹, Omid Vahidi^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 153-171, 2018, DOI:10.3970/cmes.2018.114.153

Abstract Various drugs are used to maintain normoglycemia in subjects with type 2 diabetes mellitus. The combination of the drugs from different classes in one single tablet may enhance the effectiveness of the anti-diabetic drugs. To investigate the impact of combining drugs on the glucose regulation of subjects with type 2 diabetes, we propose a pharmacokinetic/pharmacodynamics (PK/PD) mathematical modeling approach for a combination of metformin and vildagliptin drugs. In the proposed modeling approach, two separate PK models representing oral administration of metformin and vildagliptin for diabetic subjects are interconnected to a PD model comprising a detailed compartmental physiological model representing the… More >

Gaoyang Li¹, Xiaorui Song², Aike Qiao³, Makoto Ohta^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.2, pp. 143-155, 2018, DOI:10.31614/cmes.2018.04100

Abstract For patients with type 2 diabetes, the evaluation of pulse waveform characteristics is helpful to understand changes in arterial stiffness. However, there is a lack of comprehensive analysis of pulse waveform parameters. Here, we aimed to investigate the changes in pulse waveform characteristics in patients with type 2 diabetes due to increased arterial stiffness. In this study, 25 patients with type 2 diabetes and 50 healthy subjects were selected based on their clinical history. Age, height, weight, blood pressure, and pulse pressure were collected as the subjects’ basic characteristics. The brachial-ankle pulse wave velocity (baPWV) was collected as an index… More >