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  • Open Access

    REVIEW

    The Effect of Carnitine Supplementation on Left Ventricular Function: Lessons from Current Evidence and Insights for Future Studies

    Rohit S. Loomba1,2, Enrique G. Villarreal3,*, Riddhi Patel1, Samantha Udarbe1, Vincent Dorsey1, Kristen Nelson-McMillan1,4, Saul Flores5,6

    Congenital Heart Disease, Vol.15, No.6, pp. 447-455, 2020, DOI:10.32604/CHD.2020.012927 - 02 November 2020

    Abstract Introduction: In children, data on the effects on carnitine supplementation and myocardial function are limited. A few studies have investigated the relationship between serum carnitine levels in the setting of depressed cardiac function and have demonstrated possible benefits. As such, this systematic review and meta-analyses aimed to assess the effects carnitine supplementation on left ventricular function. Materials and Methods: A systematic review of the literature was performed to identify full text manuscripts in English. PubMed, EMBASE, and the Cochrane databases were queried. Studies were included with data from pediatric patients, that used carnitine supplementation and included preand… More >

  • Open Access

    ARTICLE

    Preoperative immunonutrition prior to radical cystectomy: a pilot study

    Timothy D. Lyon1, Robert M. Turner II1, Dawn McBride1, Li Wang2, Jeffrey R. Gingrich1, Ronald L. Hrebinko1, Bruce L. Jacobs1, Benjamin J. Davies1, Tatum V. Tarin1

    Canadian Journal of Urology, Vol.24, No.4, pp. 8895-8901, 2017

    Abstract Introduction: To investigate the use of a high-arginine immunonutrient supplement prior to radical cystectomy for bladder cancer.
    Materials and methods: We recruited 40 patients to consume a total of four high-arginine immunonutrient shakes per day for 5 days prior to radical cystectomy. The primary outcome measures were safety, tolerability and adherence to the supplementation regimen. Ninety-day postoperative outcomes were also compared between supplemented patients and a cohort of 104 prospectively identified non-supplemented radical cystectomy patients. Multivariable logistic regression models were used to compare overall complications, infectious complications, and readmission rates between groups.
    Results: There were no serious adverse… More >

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