Stephanie M. Ford1, Matthew T. McPheeters2, Yves T. Wang3, Pei Ma13, Shi Gu3, James Strainic4, Christopher Snyder4, Andrew M. Rollins3, Michiko Watanabe2, Michael W. Jenkins2
Congenital Heart Disease, Vol.12, No.3, pp. 322-331, 2017, DOI:10.1111/chd.12443
Abstract Background: The relationship between changes in endocardial cushion and resultant congenital
heart diseases (CHD) has yet to be established. It has been shown that increased regurgitant flow
early in embryonic heart development leads to endocardial cushion defects, but it remains unclear
how abnormal endocardial cushions during the looping stages might affect the fully septated heart.
The goal of this study was to reproducibly alter blood flow in vivo and then quantify the resultant
effects on morphology of endocardial cushions in the looping heart and on CHDs in the septated
heart.
Methods: Optical pacing was applied to create regurgitant flow in… More >
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