Giuseppe Carota¹, Lucia Di Pietro^2,3, Vincenzo Cardaci⁴, Anna Privitera^1,2, Francesco Bellia¹, Valentina Di Pietro⁵, Giuseppe Lazzarino¹, Barbara Tavazzi⁶, Angela Maria Amorini¹, Giacomo Lazzarino⁶, Giuseppe Caruso^6,7,*

BIOCELL, Vol.49, No.4, pp. 563-578, 2025, DOI:10.32604/biocell.2025.062176 - 30 April 2025

Abstract Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely distributed in excitable tissues, such as the heart and brain. Over the years, several beneficial effects of carnosine have been discussed well in scientific literature. In particular, this dipeptide is well-known for its antioxidant, anti-inflammatory, and anti-aggregation activities. It is of great interest in the context of numerous systemic and neurodegenerative diseases, besides performing important “side activities” such as metal chelation and pH-buffering. Despite a plethora of preclinical and clinical data supporting carnosine’s therapeutic potential, researchers are still searching for new pharmacological targets that better highlight More >

Danlong Jing^1,2, Nan Wang¹, Nan Lu¹, Guanzheng Qu³, Guolu Liang², Wenjun Ma¹, Shougong Zhang^1,*, Junhui Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 507-524, 2022, DOI:10.32604/phyton.2022.017644 - 26 October 2021

Abstract Lysine acetylation, a reversible and dynamic post-translational modification, plays pivotal roles in regulating many biological processes in plants. However, the information of lysine acetylation during flower development of woody angiosperm remains unclear. Herein, we identified a total of 667 lysine acetylation sites in 467 proteins in flower buds of Catalpa Bungei. The acetylated proteins were mainly involved in the pathways of carbon metabolism, glycometabolism and oxidative phosphorylation. Using functional enrichment analysis, 61 and 13 acetylated proteins were involved in the glycometabolism and oxidative phosphorylation pathways, respectively. This suggests that lysine acetylated proteins play critical roles in… More >

XINGXING ZHU^1,2, TIANFENG HUA^1,2, MINGFEI WU³, JIATIAN WU^1,2, JIANCHAO HONG^1,2, MIN YANG^1,2,*

BIOCELL, Vol.44, No.3, pp. 431-441, 2020, DOI:10.32604/biocell.2020.010323 - 22 September 2020

Abstract Post-resuscitation myocardial dysfunction (PRMD) is the most severe myocardial ischemia-reperfusion injury (MIRI) and is characterized by difficult treatment and poor prognosis. Research has shown the protective effects of the rational use of ivabradine (IVA) against PRMD; however, the molecular mechanisms of IVA remain unknown. In this study, an ischemia-reperfusion injury (IRI) model was established using hypoxic chambers. The results demonstrated that pretreatment with IVA reduced IRI-induced cytotoxicity and apoptosis. IVA attenuated mitochondrial damage, eliminated excess reactive oxygen species (ROS), suppressed IRI-induced ATP and NAD⁺ , and increased the AMP/ATP ratio. We further found that IVA increased More >