Weijuan Yao*, Lanping Amy Sung†
Molecular & Cellular Biomechanics, Vol.6, No.1, pp. 71-82, 2009, DOI:10.3970/mcb.2009.006.071
Abstract Erythrocyte tropomodulin (E-Tmod) is a tropomyosin-binding and actin capping protein at the point end of the filaments. It is part of a molecular ruler that plays an important role in generating short actin protofilaments critical for the integrity of the cell membrane. Here, with the use of \textit {E-Tmod+/lacZ} mice, we demonstrated a specific E-Tmod expression in horizontal cells (HCs) in the retina, and analyzed the stress-strain relationship of HCs, vertically oriented neurons, and retinal ganglial cells (RGC) under normal and high intraocular pressure (IOP). Since their dendrites are oriented laterally in a plane and form most complicated synapses with… More >
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