Parvane Mahdi1, Akram Pourbakht1,*, Vahid Pirhajati Mahabadi2, Alireza Karimi Yazdi3, Mahtab Rabbani Anari3, Mohammad Kamali4
Sound & Vibration, Vol.54, No.3, pp. 163-177, 2020, DOI:10.32604/sv.2020.09880
Abstract Exposure to high level of noise, may cause the permanent cochlear
synaptic degeneration. In present study, a model of noise induced cochlear synaptopathy was established and the electrophysiological and histological metrics for
its assessment was designed. 6 guinea pigs were subjected to a synaptopathic
noise (octave band of 4 kHz at 104 dB SPL, for 2-h). The amplitude growth curve
of Auditory Brainstem Response (ABR) wave-I and wave-III latency shift in presence of noise were calculated. These indexes were considered in pre-exposure,
1 day post exposure (1DPE), 1 week post exposure (1WPE) and 1 month post
exposure (1MPE) to noise.… More >
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