Natacha E PILONI, Elizabeth ROBELLO, Julián G BONETTO, Susana PUNTARULO*
BIOCELL, Vol.40, No.1, pp. 39-42, 2016, DOI:10.32604/biocell.2016.40.039
Abstract Fe is essential for human life because it constitutes the required cofactor for proteins of diverse biological
functions. However, the development of oxidative stress by exposure to excessive Fe, share signaling pathways with
other treatments including activation of redox-sensitive factors. This study was focused on the comparison on the
effects of Fe in the brain and other organs in vivo. The oxidative effects triggered by Fe overload strongly depend
not only on the administration protocol, but also on the Fe-compound used, and the studied organ. In both the liver
and the brain, Fe content drastically increased after Fe-dextran administration. However,… More >
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